期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 139, 期 35, 页码 12149-12152出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b07460
关键词
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资金
- Natural Science Foundation of China [21477120, 51538011]
- Collaborative Innovation Center of Suzhou Nano Science and Technology of the Ministry of Education of China
Biofabrication of nanomaterials is currently constrained by a low production efficiency and poor controllability on product quality compared to chemical synthetic routes. In this work, we show an attractive new biosynthesis system to break these limitations. A directed production of selenium-containing nanoparticles in Shewanella oneidensis MR-1 cells, with fine-tuned composition and subcellular synthetic location, was achieved by modifying the extracellular electron transfer chain. By taking advantage of its untapped intracellular detoxification and synthetic power, we obtained high-purity, uniform sized cadmium selenide nanoparticles in the cytoplasm, with the production rates and fluorescent intensities far exceeding the state-of-the-art biosystems. These findings may fundamentally change our perception of nanomaterial biosynthesis process and lead to the development of fine controllable nanoparticles biosynthesis technologies.
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