期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 139, 期 29, 页码 9767-9770出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b04256
关键词
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资金
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- CAS [QYZDY-SSW-SLH029]
- K.C.Wong Education Foundation
- [NSFC-21432007]
- [21572246]
We herein describe a chiral diboron-templated highly diastereoselective and enantioselective reductive coupling of isoquinolines that provided expedited access to a series of chiral substituted bisisoquinolines in good yields and excellent ee's under mild conditions. The method enjoys a broad substrate scope and good functional group compatibility. Mechanistic investigation suggests the reaction proceeds through a concerted [3,3]-sigmatropic rearrangement.
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