期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 139, 期 42, 页码 14917-14930出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b05229
关键词
-
资金
- NSF
- NSF Extreme Science and Engineering Discovery Environment (XSEDE)
- NIGMS [GM72586]
In recent years, triazolylidene carbenes have come to the forefront as important organocatalysts for a wide range of reactions. The fundamental properties of these species, however, remain largely unknown. Herein, the gas phase acidities have been measured and calculated for a series of triazolium cations (the conjugate acids of the triazolylidene carbenes) that have not been heretofore examined in vacuo. The results are discussed in the context of these species as catalysts. We find correlations between the gas phase acidity and selectivity in two Umpolung reactions catalyzed by these species; such correlations are the first of their kind. We are able to use these linear correlations to improve reaction enantioselectivity. These results establish the possibility of using these thermochemical properties to predict reactivity in related transformations.
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