期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 139, 期 3, 页码 1029-1032出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b10680
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资金
- UC Irvine
- National Institutes of Health [GM105938]
- Eli Lilly
- NSF Graduate Research Fellowship
- Direct For Mathematical & Physical Scien [1429735] Funding Source: National Science Foundation
- Division Of Chemistry [1429735] Funding Source: National Science Foundation
We report an enantioselective coupling between alpha-branched aldehydes and alkynes to generate vicinal quaternary and tertiary carbon stereocenters. The choice of Rh and organocatalyst combination allows for access to all possible stereoisomers with high enantio-, diastereo-, and regioselectivity. Our study highlights the power of catalysis to activate two common functional groups and provide access to divergent stereoisomers and constitutional structures.
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