期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 7, 期 30, 页码 4630-4637出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb00845d
关键词
-
资金
- National Natural Science Foundation of China [21505066]
- Shandong Province Higher Educational Science and Technology Program [J18KA320]
- Natural Science Foundation of Shandong Province, China [ZR2014BP004]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
The challenge in antimicrobial photothermal therapy (PTT) is to develop strategies for decreasing the damage to cells and increasing the antibacterial efficiency. Herein, we report a novel theranostic strategy based on bacteria-induced gold nanoparticle (GNP) aggregation, in which GNPs in situ aggregated on the bacterial surface via specific targeting of vancomycin and bioorthogonal cycloaddition. Plasmonic coupling between adjacent GNPs exhibited a strong hot spot effect, enabling effective surface enhanced Raman scattering (SERS) imaging of bacterial pathogens. More importantly, in situ aggregation of GNPs showed strong NIR adsorption and high photothermal conversion, allowing enhanced photokilling activity against Gram-positive bacteria. In the absence of bacterial strains, GNPs were dispersed and showed a very low photothermal effect, minimizing the side effects towards surrounding healthy tissues. Given the above advantages, the bioorthogonal theranostic strategy developed in this study may find potential applications in treating bacterial infection and even multidrug-resistant bacteria.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据