期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 139, 期 42, 页码 15114-15121出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b08190
关键词
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资金
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- National Science Foundation [DMR-1548924]
- National Institutes of Health [1S10RR23057]
- California NanoSystems Institute at the University of California, Los Angeles
Synthetic diblock copolypeptides were designed to incorporate oppositely charged ionic segments that form beta-sheet-structured hydrogel assemblies via polyion complexation when mixed in aqueous media. The observed chain conformation directed assembly was found to be required for efficient hydrogel formation and provided distinct and useful properties to these hydrogels, including self-healing after deformation, microporous architecture, and stability against dilution in aqueous media. While many promising self assembled materials have been prepared using disordered or liquid coacervate polyion complex (PIC) assemblies, the use of ordered chain conformations in PIC assemblies to direct formation of new supramolecular morphologies is unprecedented. The promising attributes and unique features of the beta-sheet-structured PIC hydrogels described here highlight potential of harnessing conformational order derived from PIC assembly to create new supramolecular materials.
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