期刊
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
卷 60, 期 8, 页码 3187-3196出版社
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.18-26245
关键词
adaptive optics scanning laser ophthalmoscopy; retinal degeneration; cones
资金
- National Institutes of Health (NIH
- Bethesda, MD, USA) [T32-EY007043]
- NIH [R01-EY023591, P30EY003176, EY002162]
- Foundation Fighting Blindness (Columbia, MD, USA)
- FDA-OOPD grant (Silver Spring, MD, USA) [R01-41001]
- Research to Prevent Blindness (New York, NY, USA)
- Claire Giannini Fund (San Carlos, CA, USA)
- Hope for Vision (Hollywood, FL, USA)
- Bright Focus Foundation (Clarksburg, MD, USA)
- Bernard A. Newcomb Macular Degeneration Fund (Mountain View, CA, USA)
- That Man May See, Inc. (San Francisco, CA, USA)
PURPOSE. To assess the relationship between cone spacing and visual acuity in eyes with rod-cone degeneration (RCD) followed longitudinally. METHODS. High-resolution images of the retina were obtained using adaptive optics scanning laser ophthalmoscopy from 13 eyes of nine RCD patients and 13 eyes of eight healthy subjects at two sessions separated by 10 or more months (mean 765 days, range 311-1935 days). Cone spacing Z-score measured as close as possible (average < 0.25 degrees) to the preferred retinal locus was compared with visual acuity (letters read on the Early Treatment of Diabetic Retinopathy Study [ETDRS] chart and logMAR) and foveal sensitivity. RESULTS. Cone spacing was significantly correlated with ETDRS letters read (rho = -0.47, 95%CI -0.67 to -0.24), logMAR (rho = 0.46, 95%CI 0.24 to 0.66), and foveal sensitivity (rho = -0.30, 95%CI -0.52 to -0.018). There was a small but significant increase in mean cone spacing Z-score during follow-up of +0.97 (95%CI 0.57 to 1.4) in RCD patients, but not in healthy eyes, and there was no significant change in any measure of visual acuity. CONCLUSIONS. Cone spacing was correlated with visual acuity and foveal sensitivity. In RCD patients, cone spacing increased during follow-up, while visual acuity did not change significantly. Cone spacing Z-score may be a more sensitive measure of cone loss at the fovea than visual acuity in patients with RCD.
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