期刊
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
卷 77, 期 1, 页码 33-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2017.01.044
关键词
colorimetry; cyclobutane pyrimidine dimers; excimer laser; minimal erythema dose; Polypodium leucotomos extract; sunburn cells; ultraviolet
类别
资金
- Ferndale Healthcare Inc.
Background: There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen. Objective: This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE). Methods: In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE. Results: Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects. Limitations: Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied. Conclusion: The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB.
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