期刊
DRUG AND ALCOHOL DEPENDENCE
卷 154, 期 -, 页码 167-173出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2015.06.039
关键词
Dopamine; Cocaine; Social status; PET imaging; [C-11](+)PHNO
资金
- National Institutes of Health
- Veteran's Administration
- Mohegan Sun Casino
- National Center for Responsible Gaming and its affiliated Institute for Research on Gambling Disorders
- Ortho-McNeil
- Oy-Control/Biotie
- Glaxo-SmithKline
- Pfizer
- Psyadon pharmaceuticals
- Forest Laboratories
Background: Previous work in healthy non-human primates and humans has shown that social status correlates positively with dopamine 2/3 receptor (D2/3R) availability imaged with antagonist radioligands and positron emission tomography (PET). Further work in non-human primates suggests that this relationship is disrupted by chronic cocaine administration. This exploratory study examined the relationship between social status and D2/3R availability in healthy (HH) and cocaine dependent (CD) humans using the D-3-preferring, agonist radioligand, [C-11](+)PHNO. Methods: Sixteen HH and sixteen CD individuals completed the Barratt Simplified Measure of Social Status (BSMSS) and underwent [C-11](+)PHNO scanning to measure regional brain D2/3R binding potentials (BPND). Correlations between BPND and BSMSS scores were then assessed within each group. Results: Within HH and CD groups, inverse associations between BSMSS score and BPND were observed in the substantia nigra/ventral tegmental area (SN/VTA) and the ventral striatum, and for the CD group alone, the amygdala. After adjusting for body mass index and age, negative correlations remained significant in the SN/VTA for HH and in the amygdala for CD subjects. Conclusion: These preliminary data utilizing a dopamine agonist tracer demonstrate, for the first time, an inverse association between social status and D2/3R availability in the D3R rich extrastriatal regions of HH and CD humans. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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