期刊
ACS APPLIED BIO MATERIALS
卷 2, 期 8, 页码 3290-3299出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.9b00313
关键词
orthopedic implant; biodegradability; magnesium implant; protective surface modification/coatings; anticorrosion; bone defect repairing
资金
- National Natural Science Foundation of China [51273091, 21204037, 50773077, 81772402, 20934005]
- National Key Technology Support Program [2015BAI08B02]
- Hong Kong Special Administration Region Earmarked Projects [CUHK4042/09P, 2160396]
- Excellent Young Scholars NSFC [81622033]
- Central University Basic Scientific Research Fund [021414380339]
- Science and Technology Projects of Jiangsu Province [BK20160633]
- Scientific Research Foundation of Graduate School of Nanjing University [2016CL12]
Biocompatible and biodegradable magnesium (Mg) and its alloys possess excellent potential as orthopedic implant biomaterials, but they corrode too quickly inside the human body to maintain such functions as supporting and fixation. In this study, we have successfully prepared a composite biomedical material with Mg as the substrate and a multilayered coating on the metal, which contains a chemical conversion layer of fluoride or phosphate, an adhesion layer, and a layer of biodegradable polylactic acid (PLA). The recorded weight loss and the release of ionic magnesium (Mg2+) in the simulated body fluid (SBF) demonstrate that the corrosion rate of the protected Mg has been reduced to 1/10 that of the unprotected bare Mg. The corrosion rate of the protected Mg can be adjusted with either the chemical conversion type or the thickness of the PLA layer. The bare and the protected Mg has been manufactured as an implant for bone defect repair of Sprague-Dawley rats. The X-ray and micro-CT images show an improved anticorrosion of the protected Mg in vivo, and the histological analysis indicates that the Mg2+ ions released at an appropriate rate are beneficial for bone growth. The preliminary tests prove that the biodegradable Mg has been effectively protected by the innovative multilayered coating, and the implant has met the required biological functions such as biocompatibility and promotion of bone growth.
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