期刊
ENVIRONMENTAL SCIENCE-NANO
卷 6, 期 8, 页码 2591-2601出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9en00473d
关键词
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资金
- Scientific Research Foundation of Graduate School of Southeast University [YBPY1945]
The potential adverse effects of nanoplastics have gradually gained significant attention. Herein, we employed Caenorhabditis elegans to investigate the possible neurotoxic effects of nanopolystyrene particles on the development and function of D-type GABAergic motor neurons. Nanopolystyrene (1000 mu g L-1) induced the neurodegeneration of D-type motor neurons in wild-type nematodes, and nanopolystyrene (>= 100 mu g L-1) further induced the neurodegeneration phenotype in nematodes with a mutation in sod-3, encoding a Mn-SOD or acs-22, which governs the functional state of the intestinal barrier. Meanwhile, nanopolystyrene (>= 10 mu g L-1) decreased head thrash and body bend, and nanopolystyrene (>= 100 mu g L-1) altered forward and backward movements in wild-type nematodes. Moreover, nanopolystyrene (>= 1 mu g L-1) decreased head thrash and body bend and nanopolystyrene (>= 10 mu g L-1) affected forward and backward movements in sod-3 or acs-22 mutant nematodes. Along with the neurotoxicity observed in nanopolystyrene-exposed nematodes, nanopolystyrene exposure induced a dynamic autophagy induction. RNAi knockdown of lgg-1 encoding a key regulator of autophagy induced susceptibility to the neurotoxic effects of nanopolystyrene particles on the development and function of D-type motor neurons, implying the association of dynamic autophagy induction with the neurotoxicity induced by nanopolystyrene particles. Our results highlight the potential neurotoxicity of long-term nanoplastic exposure in organisms.
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