期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 64, 页码 9547-9550出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc04529e
关键词
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资金
- National Key Research and Development Program of China [2017YFA0206801]
- National Natural Science Foundation of China [21431008, u1505242]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000, XDB10040304]
- Key Research Program of the Chinese Academy of Sciences [ZDRW-CN-2016-1]
Rh-catalyzed reactions of N-alkyl anilines with internal alkynes at room temperature have been developed using an in situ generated N-nitroso group as a transient oxidizing directing group. Due to mild reaction conditions, this method enabled synthesis of a broad range of N-alkyl indoles, including even two indole-based medicinal compounds. Our work disclosed the feasibility of the transient oxidizing directing group strategy in C-H functionalization reactions, which possesses the potential to enhance overall step-economy and impart new reactivity patterns to substrates.
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