4.7 Article

Overcoming inaccessibility of fluorinated imines - synthesis of functionalized amines from readily available fluoroacetamides

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CHEMICAL COMMUNICATIONS
卷 55, 期 64, 页码 9436-9439

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc04111g

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  1. National Science Center, Poland [PRELUDIUM 2018/29/N/ST5/01938]

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Although imines are convenient substrates for the synthesis of functionalized amines, they may be hard to obtain, as in the case of fluorinated imines. To aid in overcoming this issue, we propose a protocol of corresponding amine synthesis from simple fluoroacetic acid-derived amides using Schwartz's reagent.

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