A chiral signal-amplified sensor for enantioselective discrimination of amino acids based on charge transfer-induced SERS

An ultra-high sensitivity sensor with the function of chiral signal amplification has been proposed for the enantiomer discrimination of various amino acid enantiomers based on charge transfer (CT)-induced SERS spectroscopy. The introduced TiO2 in this sensor improves the CT behavior and discrimination efficiency distinctly and enantiomeric discrimination is realized even at low concentration.