期刊
DALTON TRANSACTIONS
卷 48, 期 31, 页码 11822-11828出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9dt01650c
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资金
- SERB, Govt. of India [SB/FT/CS-062/2012, EMR/2017/003035]
- UGC
- DST-INSPIRE
Two new curcumin containing octahedral ruthenium(ii) polypyridyl complexes, viz. [Ru(NN)(2)(cur)](PF6) [NN = bpy (1), phen (2)], were designed to explore the antimicrobial activity against ESKAPE pathogens, especially with the Gram-positive drug resistant S. aureus. Solid-state structural characterization by single-crystal X-ray crystallography shows the Ru-II-center in a distorted octahedral {RuN4O2} geometry. The tested compounds showed significant inhibitory activity and high selectivity (MIC = 1 mu g mL(-1), SI = 80) against a wide variety of methicillin and vancomycin-resistant S. aureus strains. Compound 1 exhibited strong anti-biofilm activity (48% reduction of biofilm) at 10x MIC compared to the other approved drugs. The murine model of Staphylococcus infection significantly reduced the mean bacterial counts when treated with complex 1 compared to vancomycin, demonstrating its antimicrobial potential in vivo.
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