期刊
INTERNATIONAL IMMUNOLOGY
卷 31, 期 9, 页码 597-606出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxz021
关键词
IL-22; mast cells; T(h)1 cells; T(h)17 cells; T(h)22 cells
类别
资金
- Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology [gm0710006h0105]
- Ministry of Education, Culture, Sports, Science and Technology of Japan [18052010, 20390024, 20054009, 20022023, 22116003, 24390017, 26670030, 15H05905, 17H03990]
- Grants-in-Aid for Scientific Research [17H03990, 26670030, 20022023, 18052010, 22116003, 15H05905, 20390024, 20054009] Funding Source: KAKEN
Prostaglandins (PGs) are the major lipid mediators in animals and which are biosynthesized from arachidonic acid by the cyclooxygenases (COX-1 or COX-2) as the rate-limiting enzymes. Prostaglandin E-2 (PGE(2)), which is the most abundantly detected PG in various tissues, exerts versatile physiological and pathological actions via four receptor subtypes (EP1-4). Non-steroidal anti-inflammatory drugs, such as aspirin and indomethacin, exert potent anti-inflammatory actions by the inhibition of COX activity and the resulting suppression of PG production. Therefore, PGE(2) has been shown to exacerbate several inflammatory responses and immune diseases. Recently, studies using mice deficient in each PG receptor subtype have clarified the detailed mechanisms underlying PGE 2-associated inflammation and autoimmune diseases involving each EP receptor. Here, we review the recent advances in our understanding of the roles of PGE(2) receptors in the progression of acute and chronic inflammation and autoimmune diseases. PGE(2) induces acute inflammation through mast cell activation via the EP3 receptor. PGE(2) also induces chronic inflammation and various autoimmune diseases through T helper 1 (T(h)1)-cell differentiation, T(h)17-cell proliferation and IL-22 production from T(h)22 cells via the EP2 and EP4 receptors. The possibility of EP receptor-targeted drug development for the treatment of immune diseases is also discussed.
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