期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 117, 期 2, 页码 182-190出版社
WILEY
DOI: 10.1002/jso.24804
关键词
complications; enucleation; outcomes; pancreas; pancreatic fistula
资金
- National Natural Science Foundation of China [81602133]
- Science and Technology Support Project of Sichuan Province [2016FZ0115]
- Application infrastructure Project of Sichuan province [2014YJ0180]
BackgroundEnucleation is increasingly used for benign or low-grade pancreatic neoplasms. Enucleation preserves the pancreatic parenchyma as well as decreases the risk of long-term endocrine and exocrine dysfunction, but may be associated with a higher rate of postoperative pancreatic fistula (POPF). The aim of this study was to assess short-term outcomes, in particular, POPF. MethodsData were collected retrospectively from all 142 patients who underwent pancreatic enucleation between 2009 and 2014 in our institution were analyzed. ResultsLesions were most frequently located in the head and uncinate process of the pancreas (60.6%), and the most common types were neuroendocrine neoplasms (52.1%). Overall morbidity was 66%, mainly due to POPF (53.5%), and severe morbidity was only 8.4%, including one death (0.7%). Clinical POPF (Grade B or C) occurred in 22 patients (15.5%). Independent risk factors for clinical POPF were age 60 years, an episode of acute pancreatitis, and cystic morphology. Tumor size, coverage, histological differentiation, and prolonged operative time were not associated with the risk of POPF. ConclusionsEnucleation is a safe and feasible procedure for benign or low-grade pancreatic neoplasms. The rate of clinical POPF is acceptable, and clinical POPF occurs more frequently in elderly patients (60 years of age), patients with cystic neoplasms, or patients with an episode of acute pancreatitis.
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