期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 116, 期 1, 页码 7-15出版社
WILEY
DOI: 10.1002/jso.24643
关键词
focal adhesion kinase; hedgehog inhibitors; hyaluronan; immunotherapy; tumor microenvironment; vitamin D
资金
- NIH [NIH 5K12CA001727-20]
The tumor microenvironment in pancreatic cancer is a complex balance of pro-and anti-tumor components. The dense desmoplasia consists of immune cells, extracellular matrix, growth factors, cytokines, and cancer associated fibroblasts (CAF) or pancreatic stellate cells (PSC). There are a multitude of targets including hyaluronan, angiogenesis, focal adhesion kinase (FAK), connective tissue growth factor (CTGF), CD40, chemokine (C-X-C motif) receptor 4 (CXCR-4), immunotherapy, and Vitamin D. The developing clinical therapeutics will be reviewed.
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