4.7 Article

A seesaw ratiometric probe for dual-spectrum imaging and detection of telomerase activity in single living cells

期刊

CHEMICAL COMMUNICATIONS
卷 55, 期 67, 页码 9967-9970

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc03870a

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资金

  1. Natural Science Foundation of China [21775081]
  2. Key Research and Development Project of Shandong Province [2018GSF121010]
  3. Postdoctoral Science Foundation of China [2015M572074]
  4. Shandong Provincial Key Laboratory Open Fund [ZDSYS-KF201501]
  5. Key Laboratory Open Fund [SATM201602]

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Herein, a seesaw ratiometric (SR) probe is designed which integrates fluorescence and surface enhanced Raman scattering (SERS) technology. Fluorescence imaging enables tracking of the spatiotemporal dynamic behaviour of telomerase. Meanwhile, SERS reverse ratiometric measurement can enable sensitive detection of telomerase activity in single living cells.

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