4.3 Article

Nucleotide excision repair in humans

期刊

DNA REPAIR
卷 36, 期 -, 页码 13-18

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ELSEVIER
DOI: 10.1016/j.dnarep.2015.09.003

关键词

DNA repair; Nucleotide excision repair; Transcription-coupled repair; Global genome repair

资金

  1. NCI NIH HHS [R01 CA091456] Funding Source: Medline

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The demonstration of DNA damage excision and repair replication by Setlow, Howard-Flanders, Hanawalt and their colleagues in the early 1960s, constituted the discovery of the ubiquitous pathway of nucleotide excision repair (NER). The serial steps in NER are similar in organisms from unicellular bacteria to complex mammals and plants, and involve recognition of lesions, adducts or structures that disrupt the DNA double helix, removal of a short oligonucleotide containing the offending lesion, synthesis of a repair patch copying the opposite undamaged strand, and ligation, to restore the DNA to its original form. The transcription-coupled repair (TCR) subpathway of NER, discovered nearly two decades later, is dedicated to the removal of lesions from the template DNA strands of actively transcribed genes. In this review I will outline the essential factors and complexes involved in NER in humans, and will comment on additional factors and metabolic processes that affect the efficiency of this important process. (c) 2015 Elsevier B.V. All rights reserved.

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