期刊
RSC ADVANCES
卷 9, 期 43, 页码 24811-24815出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra00365g
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资金
- CNRS
- Universite de Bourgogne
- French Government [ANR-10-EQPX-05-01/IMAPPI Equipex]
- Institut Universitaire de France (IUF)
- Conseil Regional de Bourgogne Franche-Comte through the Plan d'Action Regional pour l'Innovation (PARI)
- European Union through the PO FEDER-FSE 2014/2020 Bourgogne program
- European Union [608163]
A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX (R) nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with Cu-64, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging.
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