期刊
DNA REPAIR
卷 32, 期 -, 页码 24-32出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2015.04.010
关键词
Msh2-Msh6; Mlh1-Pms1; Mutagenesis; DNA replication fidelity; Mispaired base; Excision; Recombination
资金
- NIH [R01GM50006]
- NIH NSRA [F32GM106598]
- Ludwig Institute for Cancer Research
DNA mismatch repair (MMR) acts to repair mispaired bases resulting from misincorporation errors during DNA replication and also recognizes mispaired bases in recombination (HR) intermediates. Exonuclease I (Exo1) is a 5 ' -> 3 ' exonuclease that participates in a number of DNA repair pathways. Exo1 was identified as an exonuclease that participates in Saccharomyces cerevisiae and human MMR where it functions to excise the daughter strand after mispair recognition, and additionally Exo1 functions in end resection during HR. However, Exo1 is not absolutely required for end resection during HR in vivo. Similarly, while Exo1 is required in MMR reactions that have been reconstituted in vitro, genetics studies have shown that it is not absolutely required for MMR in vivo suggesting the existence of Exo1-independent and Exo1 -dependent MMR subpathways. Here, we review what is known about the Exo1 -independent and Exo1-dependent subpathways, including studies of mutations in MMR genes that specifically disrupt either subpathway. (C) 2015 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据