期刊
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 166, 期 -, 页码 1-15出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jsbmb.2016.04.009
关键词
Prostate cancer; Epigenetic; Methylation; Biomarkers; Metabolism; Mitochondria
资金
- ERC grant
- Norwegian Research Council
- Heise Sor-Ost
- University of Oslo through the Centre for Molecular Medicine (Norway)
- Nordic EMBL (European Molecular Biology Laboratory) partnership
- Belfast-Manchester Movember Centre of Excellence [CE013_2-004]
- Prostate Cancer UK
- Cancer Research UK programme grant [C14303/A20406]
- European Commission through the Horizon 2020 project SOUND [633974]
- University of Cambridge
- Cancer Research UK
- Hutchison Whampoa Limited
- Versus Arthritis
- Cancer Research UK [20406] Funding Source: researchfish
After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific consideration is given to recurrent alterations. A list of frequently reported genes is synthesized from 17 studies that have reported on methylation changes in malignant prostate tissue, and we chart the timing of those changes in the diseases history through amalgamation of several previously published data sets. We also review associations with genetic alterations and hormone signalling, before the practicalities of investigating prostate cancer methylation using cell lines are assessed. We conclude by outlining the interplay between DNA methylation and prostate cancer metabolism and their regulation by androgen receptor, with a specific discussion of the mitochondria and their associations With DNA methylation. (C) 2016 The Authors. Published by Elsevier Ltd.
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