期刊
DRUG RESEARCH
卷 69, 期 9, 页码 496-504出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-0855-8464
关键词
chitosan; citric acid; drug delivery; curcumin; magnetic nanoparticles
资金
- Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan
- Islamic Azad University, Tehran, Iran
Chitosan-coated magnetic nanoparticles are an appropriate drug delivery method which can improve the therapeutic properties of chemotherapy agents and also can be useful as MRI contrast agent for early cancer diagnosis. This research discovers the optimization of the possible therapeutic effects of Chitosan- citric acid- Fe (3) O (4) - CUR quartets. Chitosan as a natural polymer can use to encapsulate citric acid modified Fe (3) O (4) nanoparticles. The successful preparation of CUR-loaded nano-carriers was confirmed by X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM) and transmission electron microscopy (TEM) techniques. Moreover, the hemolysis test was used for the study of hemobiocompatibility. The loading capacity and encapsulation efficiency of CUR molecules were 11 +/- 0.09% and 49.5 +/- 0.41%, respectively. The anticancer effect of the void of CUR and CUR-loaded nano-carriers were compared by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on the treated MCF-7 cell lines. It can be concluded that the use of these nanoparticles are a better and more efficient approach for the controlled and slow release of CUR in the cancer treatment.
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