期刊
NANOSCALE HORIZONS
卷 4, 期 5, 页码 1037-1045出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nh00328b
关键词
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资金
- Major State Basic Research Development Program of China (973 Program) [2015CB755500]
- National Key Research and Development Program of China: Scientific and Technological Innovation Cooperation of Mainland and Macao [2017YFE0120000]
- Natural Science Foundation of China [81571745, 91859117, 81771906]
- Science and Technology Key Project of Shenzhen [JCYJ20160229200902680]
- Shenzhen Key Laboratory of Ultrasound Imaging and Therapy [ZDSYS201802061806314]
- Shenzhen Double Chain Grant [[2018]256]
- Natural Science Foundation of Guangdong Province [2014A030312006]
- China Postdoctoral Science Foundation [2019M653129]
Glioma is a malignant tumor in the central nervous system with poor prognosis, high risk of recurrence and mortality. As the primary choice of treatment for glioma, surgery cannot effectively remove glioma cells owing to the lack of advanced intraoperative navigation technology. Photoacoustic (PA) imaging, a hybrid imaging technique, integrates the merits of optical and ultrasound imaging, exhibiting great potential for cancer surgery navigation. To enhance the sensitivity and specificity for visualizing the tumor margin, abundant contrast agents have been developed for enhanced PA imaging. In this minireview, we expect to draw attention to the recent advances in constructing functional nanomaterials as PA contrast agents for glioma imaging. The design and preparation of organic and inorganic nanomaterials for glioma PA imaging are discussed in detail. Meanwhile, the current challenges and perspectives of contrast-enhanced PA imaging of glioma are presented.
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