期刊
JOURNAL OF SPINAL CORD MEDICINE
卷 41, 期 5, 页码 503-517出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10790268.2017.1361562
关键词
Spinal cord injury; Transcranial magnetic stimulation; Plasticity; Transcranial direct current stimulation; Motor recovery
资金
- Department of Defense [W81XWH1110707]
- Clinical Translational Science Collaborative (CTSC) under Grant RPC [2016-195]
- CPN Challenge, a program of Conquer Paralysis Now
- U.S. Department of Defense (DOD) [W81XWH1110707] Funding Source: U.S. Department of Defense (DOD)
Objective: Our goal was to determine if pairing transcranial direct current stimulation (tDCS) with rehabilitation for two weeks could augment adaptive plasticity offered by these residual pathways to elicit longer-lasting improvements in motor function in incomplete spinal cord injury (iSCI). Design: Longitudinal, randomized, controlled, double-blinded cohort study. Setting: Cleveland Clinic Foundation, Cleveland, Ohio, USA. Participants: Eight male subjects with chronic incomplete motor tetraplegia. Interventions: Massed practice (MP) training with or without tDCS for 2 hrs, 5 times a week. Outcome Measures: We assessed neurophysiologic and functional outcomes before, after and three months following intervention. Neurophysiologic measures were collected with transcranial magnetic stimulation (TMS). TMS measures included excitability, representational volume, area and distribution of a weaker and stronger muscle motor map. Functional assessments included a manual muscle test (MMT), upper extremity motor score (UEMS), action research arm test (ARAT) and nine hole peg test (NHPT). Results: We observed that subjects receiving training paired with tDCS had more increased strength of weak proximal (15% vs 10%), wrist (22% vs 10%) and hand (39% vs. 16%) muscles immediately and three months after intervention compared to the sham group. Our observed changes in muscle strength were related to decreases in strong muscle map volume (r=0.851), reduced weak muscle excitability (r=0.808), a more focused weak muscle motor map (r=0.675) and movement of weak muscle motor map (r=0.935). Conclusion: Overall, our results encourage the establishment of larger clinical trials to confirm the potential benefit of pairing tDCS with training to improve the effectiveness of rehabilitation interventions for individuals with SCI.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据