期刊
MATERIALS CHEMISTRY FRONTIERS
卷 3, 期 9, 页码 1786-1792出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9qm00197b
关键词
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资金
- NNSFC [61805117, 51673023, 81872255]
- China Postdoctoral Science Foundation
- Six talent peak innovation team in Jiangsu Province [TD-SWYY-009, WSW041]
- Key medical talents fund of Jiangsu Province [2016KJQWZDRC-03]
- 333 High-level Talents Training Project [BRA2016508]
- Jiangsu Provincial Graduated Training Innovation Project [KYCX18_1125]
Multimodal therapy, integrating two or more compositions with different functions into a nanoplatform, will generate the synergistic effects of the multi-components and effectively improve the tumor therapeutic efficacy. Herein, core-shell structured ZnP@PDA nanoparticles (NPs) were easily constructed via encapsulating the near-infrared (NIR) photosensitizer of zinc porphyrin nanoparticles (ZnP NPs) with polydopamine (PDA). The ZnP@PDA NPs displayed good biocompatibility and could effectively prevent aggregation after intravenous injection. Triggered by a NIR laser, the ZnP@PDA NPs exhibited excellent photodynamic performance. Furthermore, compared with PDA or ZnP NPs, the ZnP@PDA NPs showed improved photothermal performance with a high photothermal conversion efficiency (PCE) of 46.8% due to the triplet exciton quenching and fluorescence resonance energy transfer (FRET). In vitro and in vivo evaluations demonstrated that the ZnP@PDA NPs could directly target the tumor site via the enhanced permeability and retention (EPR) effect and exhibited strong phototoxicity and outstanding tumor phototherapeutic efficacy.
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