期刊
ARKIVOC
卷 -, 期 -, 页码 69-79出版社
ARKAT USA INC
DOI: 10.24820/ark.5550190.p010.882
关键词
Alkylation; flow chemistry; one-pot process; reduction; sulfonyl indoles
资金
- University of Camerino
Reduction of 3-(1-arylsulfonylalkyl) indoles (sulfonyl indoles) using polymer-supported sodium borohydride under flow chemical conditions allows an efficient synthesis of 3-alkylindoles with a notable waste minimization and reduced solvent consumption. The flow conditions can be also applied to the synthesis of sulfonyl indoles which can be obtained by a three-component coupling of indoles with aldehydes and p-toluenesulfinic acid. Using the two-step flow chemical approach, 3-alkylindoles can be directly obtained from their remote indole and aldehyde precursors. [GRAPHICS] .
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