期刊
JOURNAL OF SEPARATION SCIENCE
卷 41, 期 3, 页码 697-703出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201700774
关键词
96-well plate; cork; emerging contaminants; liquid chromatography; thin-film microextraction
资金
- National Council for Scientific and Technological Development (CNPq-Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
In this study, a newmethodwas developed in which a biosorbent material is used as the extractor phase in conjunction with a recently described sample preparation technique called thin-film microextraction and a 96-well plate system. The method was applied for the determination of emerging contaminants, such as 3-(4-methylbenzylidene) camphor, ethylparaben, triclocarban, and bisphenol A in water samples. The separation and detection of the analytes were performed by high-performance liquid chromatography with diode array detection. These contaminants are considered hazardous to human health and other living beings. Thus, the development of an analytical method to determine these compounds is of great interest. The extraction parameters were evaluated using multivariate and univariate optimization techniques. The optimum conditions for the method were 3 h of extraction time, 20min of desorption with 300 mu L of acetonitrile and methanol (50: 50, v/v), and the addition of 5% w/v sodium chloride to the sample. The analytical figures of merit showed good results with linear correlation coefficients higher than 0.99, relative recoveries of 72-125%, interday precision (n = 3) of 4-18%, and intraday precision (n = 9) of 1-21%. The limit of detection was 0.3-5.5 mu g/L, and the limit of quantification was 0.8-15 mu g/L.
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