期刊
JOURNAL OF SEPARATION SCIENCE
卷 40, 期 24, 页码 4700-4708出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201700719
关键词
atom transfer radical polymerization; diblock copolymers; ion exchange; mixed-mode chromatography; stationary phases
资金
- National Natural Science Foundation of China [21475104, 21775121, 21575114]
- Industry Development Project by Science and Technology Department of Shaanxi Province [2016GY-214]
- Scientific Research Program - Shaanxi Provincial Education Department [17JS134]
A novel approach that involved the grafting of diblock copolymer with two types of monomer onto substrate by sequential surface initiated-atom transfer radical polymerization was proposed to prepare amixed-mode chromatographic stationary phase. The distinguishing feature of this method is that it can be applied in the preparation of various mixed-mode stationary phases. In this study, a new reverse-phase/ion-exchange stationary phase was prepared by grafting hydrophobic styrene and cationic sodium 4-styrenesulfonate by the proposed approach onto silica surface. The chromatographic properties of the prepared stationary phase were evaluated by the separation of benzene derivatives, anilines, and beta-agonists, and by the effect of pH values and acetonitrile content on the retention. Compared with typical RP columns, the prepared stationary phase achieved the better resolution and higher selectivity at a shorter separation time and lower organic content. Moreover, the application of the prepared column was proved by separating widely distributed polar and charged compounds simultaneously.
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