期刊
ENEURO
卷 6, 期 4, 页码 -出版社
SOC NEUROSCIENCE
DOI: 10.1523/ENEURO.0244-18.2019
关键词
associative learning; C. elegans; chemotaxis; PA14; sensory integration
资金
- Natural Sciences and Engineering Research Council of Canada [501100000038]
- NIH Office of Research Infrastructure Programs [P40 OD010440]
Associative learning and sensory integration are two behavioral processes that involve the sensation and processing of stimuli followed by an altered behavioral response to these stimuli, with learning requiring memory formation and retrieval. We found that the cellular and molecular actions of scd-2 dissociate sensory integration and associative learning. This was discovered through investigation of a Caenorhabditis elegans mutation (Irn-2 (mm99)) affecting both processes. After mapping and sequencing, Irn-2 was found to be allelic to the gene, scd-2. scd-2-mediated associative learning and sensory integration operate in separate neurons as separate processes. We also find that memories can form from associations that are processed and stored independently from the integration of stimuli preceding an immediate behavioral decision.
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