期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 7, 期 34, 页码 5170-5181出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb00991d
关键词
-
资金
- National Research Programs of China [2016YFA0201200]
- National Natural Science Foundation of China [51525203, 51761145041, 51572180, 81772773, 81672560, 81302275]
- Jiangsu Natural Science Fund for Distinguished Young Scholars [BK20170063]
- Jiangsu Provincial Medical Youth Talent [QNRC2016753]
- Project of Jiangsu Provincial Maternal and Child Health Association [FYX201709]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [SJCX18_0853]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
Radiotherapy (RT) has been used clinically to overcome cancer in recent decades. However, the abnormal tumor microenvironment (TME), involving hypoxia, acidosis and a dense extracellular matrix, is found to be related to the resistance of tumors to RT. Herein, intelligent bovine serum albumin (BSA)-coated Bi2S3 and MnO2 (Bi2S3-MnO2) nanocomposites synthesized via biomineralization are capable of modulating the hypoxic TME effectively to enhance the efficacy of RT. After intravenous injection, the BSA-Bi2S3-MnO2 nanocomposites show efficient accumulation in tumors, where endogenous H2O2 can react with MnO2 to generate oxygen in situ, leading to increased tumor oxygenation to overcome the hypoxia-associated resistance to RT. Moreover, the photothermal effect induced by the BSA-Bi2S3-MnO2 nanocomposites further relieves hypoxia in the TME and, finally, synergistically improves the effects of RT. In this work, we present a simple strategy to fabricate intelligent therapeutic nanoparticles to improve therapeutic efficiency towards cervical cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据