期刊
DATA IN BRIEF
卷 24, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.dib.2019.103909
关键词
Transcriptomics; Circadian rhythms; SOX2; Suprachiasmatic nucleus; Mice
资金
- Canadian Institutes of Health Research (CIHR)
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- NSERC Tier II Canada Research Chair in Molecular Genetics of Biological Clocks
- NSERC
- Canadian Foundation for Innovation
SOX2 is a stem cell-associated pluripotency transcription factor whose role in neuronal populations is undefined. Here we present the RNA-sequencing based transcriptome profiles of control (Sox2(fl/fl)) and SOX2 conditional knock-out (Vgat-cre; Sox2(fl/fl)) mice at four time points in one 24-h circadian cycle. The raw sequencing data were deposited to ArrayExpress database at EMBL-EBI (https://www.ebi.ac.uk/arrayexpress) under the accession number E-MTAB-7496. Results of rhythmicity analysis, differential expression analysis, network prediction, and potential target identification stemming from the RNA-sequencing dataset are also given in this article. The interpretation and discussion of these data can be found in the related research article entitled SOX2-dependent transcription in clock neurons promotes the robustness of the central circadian pace-maker. Cheng et al. 2019. (C) 2019 The Authors. Published by Elsevier Inc.
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