期刊
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 121, 期 -, 页码 1-10出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2017.04.007
关键词
Pregnancy; T-FH cells; Estrogen; Antibodies
资金
- Fundacao de Amparo a Pesquisa Carlos Chagas Filho (FAPERJ)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Pregnancy favors antibody production, and some evidence has suggested a direct effect of estrogen on B cells. The impact of pregnancy on circulating follicular helper T (T-FH) cells, typically identified by the expression of CD45RO and CXCR5, has not been previously investigated. Here, the percentage of T-FH cells, co-expressing or not PD-1, ICOS, or CXCR3 markers was significantly higher in pregnant women (PW) as compared with non-pregnant ones (nPW). Furthermore, the percentage of CXCR3(+) TFH cells able to produce IL-6, IL-21, and IL-10 was significantly higher in PW than nPW. Interestingly, anti-CMV and anti-HBs antibody titers were significantly higher in the plasma of PW and were directly correlated with IL-21-producing CXCR3(+) T-FH cells. Finally, peripheral estrogen levels, but not progesterone, were positively related to either PD-1(+) CXCR3(+) T-FH cells or plasma anti-CMV and anti-HBs IgG antibodies. In summary, our data suggests a positive effect of pregnancy on the proportion of CD4(+) T cell subset specialized in helping B cells. This phenomenon, which could be related to the high estrogen levels produced during pregnancy, may help to explain why pregnancy favor humoral immunity.
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