期刊
REACTION CHEMISTRY & ENGINEERING
卷 4, 期 9, 页码 1608-1615出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9re00096h
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资金
- INCa Institut National du Cancer
- Region des Pays de la Loire
- INCa
Pyridine-oxazoline-type ligands (PyOX) are an important class of chiral ligands for metal-catalyzed asymmetric transformations. Herein we describe an efficient and reliable flow route which is amenable for the synthesis of PyOX ligands at a scale of hundreds of milligrams per hour. Optimal flow conditions were rapidly identified through the assistance of an in-house built autonomous self-optimizing system integrating a custom-made optimization algorithm derived from the Nelder-Mead and golden section search methods. The preparation of a small library of representative PyOX ligands highlights the practical application of this flow route which should be of primary interest for synthetic chemists developing metal-catalyzed asymmetric transformations.
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