期刊
CHEMICAL SCIENCE
卷 10, 期 30, 页码 7251-7259出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc02162k
关键词
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资金
- ETH Zurich
- ETH Postdoctoral Fellowship Program
We report a mild approach to the synthesis of difluoro(aryl)-lambda(3)-iodanes (aryl-IF2 compounds) and tetrafluoro(aryl)-lambda(5)-iodanes (aryl-IF4 compounds) using trichloroisocyanuric acid (TCICA) and potassium fluoride (KF). Under these reaction conditions, selective access to either the I(iii)- or I(v)-derivatives is predictable based solely on the substitution pattern of the iodoarene starting material. Moreover, the discovery of this TCICA/KF approach prompted detailed dynamic NMR, kinetic, computational, and crystallographic studies on the relationship between the IF2 group and the ortho-substituents on carefully designed probe molecules. It was during these experiments that the role of the ortho-substituent in inhibiting further oxidative fluorination of I(iii)-compounds to I(v)-compounds during the reaction with TCICA and KF was revealed. Additionally, a notable exception to this empirical trend is discussed herein.
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