期刊
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
卷 314, 期 1, 页码 111-118出版社
SPRINGER
DOI: 10.1007/s10967-017-5345-4
关键词
Tumor hypoxia; 3-Nitrotriazole; PET imaging; PnAO
资金
- National Natural Science Foundation of China [21371017, 81371592, 11575010]
The propylene amine oxime (PnAO) ligand, PnAO-1, 1'-bis(3-nitrotriazole) (3P3) with two 3-nitrotriazole groups was labeled with (CuCl2)-Cu-64. In vitro results suggest that Cu-64-3P3 can accumulate in hypoxic S180 tumor cells. Biodistribution studies of Cu-64-3P3 in mice bearing S180 tumor demonstrate that the tumor uptake, tumor-to-muscle ratio, and tumor-to-blood ratio are considerable. A tumor area could also be found in positron emission tomography imaging 18 h post-administration. For comparison, the classical hypoxia imaging agent Cu-64-ATSM was also investigated. The experimental data obtained demonstrate that Cu-64-3P3 may potentially be used as an efficient hypoxia imaging agent.
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