期刊
CELL ADHESION & MIGRATION
卷 13, 期 1, 页码 273-284出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2019.1639303
关键词
CRC; TIMP-2; MMP-9; prognosis; metastasis
类别
资金
- National Natural Science Foundation of China [81773944]
- Young Medicine Focus Talent Foundation of Jiangsu Province [QNRC2016206]
- Postgraduate Research by Practice Innovation Program of Jiangsu Province [KYCX18_2382]
- Natural Science Foundation of Jiangsu Province for Youths [BK20170516]
- Natural Science Foundation of Jiangsu Province [BK20180927]
- Wuxi City Health Planning Commission project [MS201815]
Colorectal cancer has a common cause of morbidity and mortality. Therefore, it is urgent to detect reliable biomarkers to predict prognosis in CRC. Here, we determined the expression of TIMP-2 and MMP-9 in a CRC tissue microarray by immunohistochemistry. We found that lower TIMP-2 or/and higher MMP-9 expression in cancer tissues was correlated with poorer overall survival (OS). TIMP-2 or MMP-9 expression was independent prognostic factors for CRC. Furthermore, TIMP-2 and MMP-9 expression had a synergistic role as efficient prognostic indicators for CRC patients. In vitro and in vivo, TIMP-2 could inhibit HCT 116 cells invasion and migration by regulating MMP-9. In sum, a combined expression of TIMP-2 and MMP-9 as efficient prognostic indicators was found for the first time.
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