相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Structure-based discovery of opioid analgesics with reduced side effects
Aashish Manglik et al.
NATURE (2016)
A randomized, phase 2 study investigating TRV130, a biased ligand of the mu-opioid receptor, for the intravenous treatment of acute pain
Eugene R. Viscusi et al.
PAIN (2016)
Effects of Repeated Morphine on Intracranial Self-Stimulation in Male Rats in the Absence or Presence of a Noxious Pain Stimulus
Laurence L. Miller et al.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY (2015)
Effects of the novel, selective and low-efficacy mu opioid receptor ligand NAQ on intracranial self-stimulation in rats
Ahmad A. Altarifi et al.
PSYCHOPHARMACOLOGY (2015)
First Clinical Experience With TRV130: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers
David G. Soergel et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2014)
Site and mechanism of morphine tolerance in the gastrointestinal tract
H. I. Akbarali et al.
NEUROGASTROENTEROLOGY AND MOTILITY (2014)
Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers
David G. Soergel et al.
PAIN (2014)
Biased ligands at G-protein-coupled receptors: promise and progress
Jonathan D. Violin et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2014)
Intracranial Self-Stimulation to Evaluate Abuse Potential of Drugs
S. Stevens Negus et al.
PHARMACOLOGICAL REVIEWS (2014)
Abuse-related effects of μ-opioid analgesics in an assay of intracranial self-stimulation in rats: modulation by chronic morphine exposure
Ahmad A. Altarifi et al.
BEHAVIOURAL PHARMACOLOGY (2013)
Structure Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]a2[(9R)-9-(pyridin-2-y1)-6-oxaspiro-[4.5]clecan-9-yl]ethylpamine (TRV130), for the Treatment of Acute Severe Pain
Xiao-Tao Chen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphines
Scott M. DeWire et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Reversal of Morphine Analgesic Tolerance by Ethanol in the Mouse
L. C. Hull et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: New concepts in mu opioid receptor pharmacology: From a symposium on new concepts in mu-opioid pharmacology
Kenneth Lamb et al.
DRUG AND ALCOHOL DEPENDENCE (2012)
Differences in the characteristics of tolerance to μ-opioid receptor agonists in the colon from wild type and β-arrestin2 knockout mice
Hercules T. Maguma et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2012)
The Role of β-Arrestin2 in the Mechanism of Morphine Tolerance in the Mouse and Guinea Pig Gastrointestinal Tract
Minho Kang et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Some determinants of morphine effects on intracranial self-stimulation in rats: dose, pretreatment time, repeated treatment, and rate dependence
Ahmad A. Altarifi et al.
BEHAVIOURAL PHARMACOLOGY (2011)
The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics
Kirsten M. Raehal et al.
NEUROPHARMACOLOGY (2011)
Morphine Tolerance in the Mouse Ileum and Colon
Gracious R. Ross et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Morphine side effects in beta-arrestin 2 knockout mice
KM Raehal et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)