期刊
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
卷 42, 期 5, 页码 294-299出版社
CMA-CANADIAN MEDICAL ASSOC
DOI: 10.1503/jpn.170137
关键词
-
资金
- Canadian Institutes of Health Research [377213/ 201610PJT]
- Bucke Family Fund and Opportunities Fund
- Academic Medical Organization of South Western Ontario
The prepsychotic phase of schizophrenia is not only important for indicated prevention strategies, but also crucial for developing mechanistic models of the emergence of frank psychosis (transition). This commentary highlights the work of Dukart and colleagues, published in this issue of the Journal of Psychiatry and Neurosicence, who sought to identify MRI-based anatomic endophenotypes of psychosis in a well-characterized sample of patients with at-risk mental state (ARMS) and first-episode psychosis (FEP). Conceptual and translational challenges in clarifying the neurobiology of transitional prepsychotic states are discussed. A role of intracortical myelin in the neurobiology of transition is proposed. Transition may not be an outcome of progressive structural deficits; it may occur due to inadequate compensatory responses in the predisposed. The need to revise our current deficit-oriented models of neurobiology of psychosis in the wake of burgeoning evidence indicating a dynamic process of cortical reorganization is emphasized.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据