期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 90, 期 -, 页码 67-77出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2017.02.009
关键词
Psychosis; Schizophrenia; Treatment; Attrition; Retention; Review
类别
Essential criteria for the methodological quality and validity of randomized controlled trials are the dropout rates from both the experimental intervention and the study as a whole. This systematic review and meta-analysis assessed these drop-out rates in non-pharmacological schizophrenia trials. A systematic literature search was used to identify relevant trials with >= 100 sample size and to extract the drop-out data. The rates of drop-out from the experimental intervention and study were calculated with meta analysis of proportions. Meta-regression was applied to explore the association between the study and sample characteristics and the drop-out rates. 43 RCTs were found, with drop-out from intervention ranging from 0% to 63% and study drop-out ranging from 4% to 71%. Meta-analyses of proportions showed an overall drop-out rate of 14% (95% CI: 13-15%) at the experimental intervention level and 20% (95% CI: 17-24%) at the study level. Meta-regression showed that the active intervention drop-out rates were predicted by the number of intervention sessions. In non-pharmacological schizophrenia trials, drop-out rates of less than 20% can be achieved for both the study and the experimental intervention. A high heterogeneity of drop-out rates across studies shows that even lower rates are achievable. (C) 2017 Elsevier Ltd. All rights reserved.
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