期刊
ANALYST
卷 144, 期 18, 页码 5449-5454出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9an01087d
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资金
- Department of Defense, Chemical and Biological Defense [W911QY19C0008]
- National Institute of Health, National Institute of Drug Abuse [2R44DA032178-02]
A simple-to-use device to measure drugs in saliva, blood plasma, and whole blood for point-of-care analysis and treatment of overdose patients has been investigated. A rudimentary flow strip has been developed to separate opioids from these biofluids for analysis by surface-enhanced Raman spectroscopy (SERS). The strips are based on lateral flow assays, in which the antibodies have been substituted by SERS-active pads for detection. Samples of codeine and fentanyl, artificially added to these biofluids, were measured using the strips by a field-usable Raman spectrometer. We report measurement of these drugs in these biofluids from 0.5 to 5 mu g mL(-1) in 5 minutes. Calculated limits of detection for the spectra suggest that these drugs could be measured at 5 to 20 ng mL(-1) with improvements in the strips' separation capability.
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