期刊
NEW JOURNAL OF CHEMISTRY
卷 43, 期 35, 页码 13751-13763出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nj02026h
关键词
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资金
- CNPq [151150/2018-4, PQ 305741/2017-9, 404466/2016-8]
- FAPEMIG [PPM-00638-16, PPM-00635-18]
- FAPEMIG (Rede de Pesquisa e Inovacao para Bioengenharia de Nanossistemas) [RED-00282-16]
- FAPERJ
- CAPES
- INCT-Catalise
- Capes [88881.145517/2017-01]
- Service de Chimie Bioorganique et de Marquage'', Laboratory of Excellence in Research on Medication and Innovative Therapeutics [ANR-10-LABX-0033-LERMIT]
We report a new method for A-ring selenation of naphthoquinones and anthraquinones and discuss the relevant trypanocidal activity of the synthesized compounds. We have demonstrated three efficient strategies for the preparation of the target selenium derivatives, i.e. (a) copper(i) thiophene-2-carboxylate and in situ generated Santi's reagent were used to prepare selenium-substituted benzenoid quinones, (b) copper complexes and (c) carbon nanotube-supported copper ferrite as catalysts in the presence of AgSeR-salts were also used for the synthesis of selenium-containing quinoidal derivatives. These new methods provide efficient and practical strategies for the preparation of selenium-based quinones. In addition, we have discovered nine compounds with potent trypanocidal activity. The derivatives 2a-2e showed potent trypanocidal activity with IC50 values in the range of 13.3 to 37.0 mu M.
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