期刊
MATERIALS HORIZONS
卷 6, 期 8, 页码 1538-1547出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9mh00664h
关键词
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资金
- Australian Centre for Nanomedicine
- ARC centre of Excellence in Convergent Bio-Nano Science and Technology [CE140100036]
- ARC Laureate Fellowship program [FL150100060]
- National Health and Medical Research Council [1091261]
- ARC Centre of Excellence in Advanced Molecular Imaging [CE140100011]
- Australian Research Council [LP140100967, DP130100269, LP150101014, DP190102659]
- National Health and Medical Research Council of Australia [1059278, 1037320]
- National Health and Medical Research Council of Australia [1091261] Funding Source: NHMRC
This article focuses on how nanoparticle shape affects the cellular internalisation and transport of nanoparticles inside cells and what the different analytical methods for determining nanoparticle internalisation by cells tell us. Rod-shaped nanoparticles typically show greater cellular internalisation relative to spherical nanoparticles, although there are studies with contradictory conclusions. The contradiction may be a result of differences in the materials being used in the comparison and/or a result of the analytical method employed. Finally, future opportunities in studying cellular internalisation with 3D cell-culture models and light-sheet microscopy are discussed.
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