期刊
BIOMATERIALS SCIENCE
卷 7, 期 10, 页码 3942-3960出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9bm00831d
关键词
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资金
- National Key RAMP
- D Program of China [2017YFA0207900]
- Recruitment Program of Global Experts [D1424002A]
- Sichuan Science and Technology Program [2018RZ0134]
Calcium phosphate (CaP) was engineered as a drug delivery nanocarrier nearly 50 years ago due to its biocompatibility and biodegradability. In recent years, several approaches have been developed for the preparation of size-controllable, stable and multifunctional CaP nanocarriers, and several targeting moieties have also been decorated on the surface of these nanocarriers for active targeting. The CaP nanocarriers have been utilized for loading probes, nucleic acids, anticancer drugs and photosensitizers for cancer imaging, therapy and theranostics. Herein, we reviewed the recent advances in the preparation strategies of CaP nanocarriers and the applications of these nanocarriers in tumor diagnosis, gene delivery, drug delivery and theranostics and finally provided perspectives.
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