期刊
JOURNAL OF PHYSICS-CONDENSED MATTER
卷 29, 期 23, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1361-648X/aa6c9d
关键词
ionic liquids; free energy; proteins; preferential binding model; Kirkwood-Buff theory; chemical activity
资金
- Deutsche Forschungsgemeinschaft [Sonderforschungsbereich 716 (SFB 716)]
- Deutsche Forschungsgemeinschaft through cluster of excellence initiative Simulation Technology [EXC 310]
Ionic liquids (ILs) are used in a variety of technological and biological applications. Recent experimental and simulation results reveal the influence of aqueous ionic liquids on the stability of protein and enzyme structures. Depending on different parameters like the concentration and the ion composition, one can observe distinct stabilization or denaturation mechanisms for various ILs. In this review, we summarize the main findings and discuss the implications with regard to molecular theories of solutions and specific ion effects. A preferential binding model is introduced in order to discuss protein-IL effects from a statistical mechanics perspective. The value of the preferential binding coefficient determines the strength of the ion influence and indicates a shift of the chemical equilibrium either to the native or the denatured state of the protein. We highlight the role of water in order to explain the self-association behavior of the IL species and discuss recent experimental and simulation results in the light of the observed binding effects.
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