期刊
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY
卷 38, 期 5, 页码 390-394出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/01676830.2018.1553190
关键词
Periocular dermatitis; dupilumab; atopic dermatitis; allergic contact dermatitis; adverse effect
资金
- Research to Prevent Blindness
Dupilumab is a monoclonal antibody used to treat atopic dermatitis. Worsening of atopic dermatitis and conjunctivitis following dupilumab use are reported adverse effects; however, there is little reported on the nature and mechanism of these complications. Here, we describe two patients with chronic atopic dermatitis who developed new or severely worsened periocular dermatitis, believed to be a side effect of dupilumab injections, and resolution after its discontinuation. We explore the possibility of dupilumab-induced suppression of Th2 mediated inflammation and upregulation of Th1 and IFN gamma mediated inflammation as a possible mechanism.
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