期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 17, 期 36, 页码 8408-8416出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob01395d
关键词
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资金
- Key R&D Project of Shandong Province [2018GSF118022]
- National Natural Science Foundation of China [21772181, 21572154, 81803344]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Fundamental Research Funds for the Central Universities [201612013]
- Qingdao Scientific and Technological Innovation Center for Marine Biomedicine Development Grant [2017-CXZX01-1-1]
TfOH-mediated [4 + 2] cycloaddition of ynamides with nitriles to construct 1,2-dihydroquinazolines is realized by a direct reaction in moderate to excellent yields (up to 93%) in a stereospecific manner. A rapid and efficient strategy has been employed for the syntheses of alkyl-substituted 1,2-dihydroquinazoline derivatives, and it exhibits good functional group tolerance, has a short reaction time, shows excellent diastereoselectivity, and is a simple and high-yielding reaction.
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