期刊
JOURNAL OF PHYSICAL CHEMISTRY C
卷 121, 期 12, 页码 6955-6961出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcc.6b11799
关键词
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资金
- Project INSIDE POR CREO FESR [CUP ST: 3389.30072014.067000001]
Photoacoustic imaging (PAI) is a promising noninvasive technique for molecular and cellular characterization of cancer. Cancer detection by PAI is an area of active research, and the recent advent of contrast agents based on near-infrared (NIR)absorbing dyes or organic/inorganic nanoparticles tremendously improved the specificity and the signal contrast. Here we report the photoacoustic (PA) signal enhancement produced by biodegradable passion fruit-like nanoarchitectures in phantoms and ex vivo. By this approach, the synergistic interaction between commercial NIR-fluorophores and ultrasmall metal nanoparticles is exploited to produce a PA signal enhancement in the biological window. Moreover, the degradation of the nanoarchitectures is investigated in physiological environment as reference matrix.
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