期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 77, 页码 11603-11606出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc05252f
关键词
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资金
- Shanghai Pujiang Program [18PJD010]
- Fundamental Research Funds for the Central Universities [222201814019]
- Natural Science Foundation of Shanghai [19ZR1412300]
A copper-catalyzed enantioselective alkynylation between terminal alkynes and pyrazole-4,5-diones has been developed. With 2.5 mol% CuI and 3 mol% chiral ligand L15, chiral propargylic alcohols bearing a pyrazolone motif were produced in 82-99% yield and up to 98% ee. Moreover, both enantiomers of the chiral propargylic alcohols were obtained with ligands L12 and L15, respectively.
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